Oral Pills: Orally delivered hormones (pills) will pass through the liver prior to entering the bloodstream. This is called “first pass” metabolism. This has been shown to increase the risk of blood clotting and increased risk of heart attack and stroke, even if the hormone is bio-identical. In addition, when the liver metabolizes hormones it increases a protein called SHBG (sex hormone Continue Reading about What Are the Four Primary Types of Bio-Identical Hormone Therapy and the Differences Between Them?